US 4,873,355 F.W. Hobbs and J. L. Meek. Process for
regioselectively preparing phosphorylated inositols and other cyclitols, 1989.
US 4,924,023 F.W. Hobbs and J. L. Meek. Phosphorylated inositols, 1990.
Publications
(73)
Klabe, R.M., Ala, P.J.,
Erickson-Viitanen, S., and Meek, J.L., Resistance
to HIV protease Inhibitors: A comparison of enzyme inhibition and antiviral
potency. Biochemistry. 37: 8735-8742, 1998.
Hodge C.N.; Aldrich, P.E.; Bacheler,
L.T.; Chang, C.H.; Eyermann, C.J.; Garber, S; Grubb
M; Jackson, D.A.; Jadhav, P.K.; Korant, B.; Lam, P.Y.; Maurin,
M.B.; Meek, J.L.; Otto, M.J.;
Rayner, M.M.; Reid, C; Sharpe T.R.; Shum,
L.; Winslow, D.L.; Erickson-Viitanen, S.
Improved
cyclic urea inhibitors
of the HIV protease: synthesis,
potency, resistance profile,
human pharmacokinetics and
X-ray crystal structure of DMP 450. Chem Biol : 3, 301-14, 1996.
Jadhav, P.K., Woerner, F.J., Lam, P.Y.S., Hodge, C. N., Eyermann, C.J., Man, H-W., Daneker, W.F.,
Bacheler, L.T., Rayner, M.M., Meek, J. L., Erickson-Viitanen, S.,
Jackson, D.A., Calabrese, J.C., Schadt,
M., and Chang, C-H Nonepeptide Cyclic
cyanoguanidines as HIV-1 Protease inhibitors: Synthesis, Structure Activity
Relationships and X-ray crystal structure studies. J. Med. Chem, 41: 1446-1455, 1998.
Erickson-Viitanen,
S., Klabe, R.M., Cawood, P.G., O'Neal, P. and Meek, J. L., Potency and
selectivity of inhibition of the HIV protease by a small nonpeptide cyclic
urea, DMP 323, Antimicrobial Agents and
Chemotherapy, 38: 1628-1634, 1994.
Lam, P.Y.,
Jadhav, P.K., Eyermann, C.J., Hodge, C.N., Ru, Y., Bacheler, L.T., Meek, J.L.,
Otto, M.J., Rayner, M., Wong, Y.N., Chang, C.H., Weber, P.C., Jackson, D.A.,
Sharpe, T.R., and Erickson-Viitanen, S ., Rational Design of Potent,
Bioavailable, Nonpeptide cyclic ureas as HIV Protease Inhibitors. Science, 263: 380-384, 1994.
Meek,
J.L., Rice. T. J., and Anton, E., Rapid Purification of Inositol Monophosphate
Phosphatase from Beef Brain. Biochem. Biophys. Res. Comm, 156: 143,
1988.
Meek,
J.L., Davidson, F., and Hobbs, F. W., Jr. Synthesis of Inositol Phosphates. J.
Am. Chem. Soc. 110,: 2317, 1988.
Thiebert,
A.B., Suttapone, S., Worley, P.F., Baraban, J.M., Meek, J.L., and Snyder. S.H.
Demonstration of Inositol 1,3,4,5 tetrakisphosphate receptor binding. Biochem.
Biophys. Res. Comm., 148: 1283, 1987.
Berry,
J. Al, Lorimer, G.H.; Pierce, J., Seemann, J.R., Meek, J.L., and Freas, S.
Isolation, Identification, and synthesis of 2-carboxyarabinitol 1 phosphate, a
diurnal regulator of ribulose-bisphosphate carboxylase activity. Proc. Natl.
Acad. Sci.(USA) 84: 734-738,
1987
Meek,
J.L., Inositol bis, tris and tetrakis phosphates: analysis in tissues by HPLC.
Proc. Natl Acad. Sci (USA), 83:
4162-4166, 1986
Meek, J.L., and Nicoletti, F. Detection of
Inositol trisphosphate and other organic phosphates by HPLC using an enzyme
loaded post column reactor. J. Chrom. 351: 303-311, 1986.
Nicoletti,
F., J.L. Meek, M.J. Iadarola, D.M. Chuang, B.L. Roth, and E. Costa Coupling of
Inositol Phospholipid Metabolism with excitatory amino acid recognition sites
in rat hippocampus. J. Neurochem., 46: 40-46, 1985.
Eva,
C., J.L. Meek, and E. Costa: Vasoactive Intestinal Peptide which coexists with
acetylcholine decreases acetylcholine turnover in mouse salivary glands. J.
Pharmacol. exp. Therap. 232,: 670-674, 1985.
Nicoletti,
F., Grandison, L., and Meek, J.L.: Effects of repeated administration of
estradiol benzoate on tuberoinfundibular GABAergic activity in male rats. J.
Neurochem., 44: 1217-1220, 1985.
Nicoletti,
F., and Meek, J.L., Estradiol benzoate
decreases nigral GABAergic activity in male rats. Brain Research 332:
179-183, 1985.
Wroblewski,
J.T., Blaker, W.D. and Meek, J.L. Ornithine as a precursor of neuronal
glutamate: effect of canaline on ornithine aminotransferase activity and
glutamate content in the septum of rat brain. Brain Research 329: 161-168,
1985.
Quach,
TT., Tang, F., Kageyama, H., Mocchetti, I., Guidotti, A., Meek, J.L., Costa,
E., and Schwartz, J.P.: Enkephalin biosynthesis in adrenal medulla-modulation
of proenkephalin messenger RNA content of cultured chromaffin cells by 8
bromoadenosine3'5' monophosphate. Mol. Pharmacol., 26: 255-260, 1984.
Eva,
C. M. Hadjiconstantinou, Neff, N.H., and Meek, J.L.,: Acetylcholine measurement
by HPLC using an enzyme loaded post-column reactor. Analytical Biochem, 143,:
330-324, 1984.
Giorgi,
O., and Meek, J.L. Sulfation of Peptides and simple phenols by rat brain
phenolsulfotransferase: inhibition by dichloronitrophenol. Biochem. Pharmacol.,
34: 45-49, 1984.
Meek,
J.L. and Eva, C.: Enzymes adsorbed to an ion exchanger as a post-column
reactor: application to acetylcholine measurement. J. Chrom., 317:
343-348, 1984.
Meek,
J.L.: Teflon tubing as a removable replacement for steel ferrules in HPLC.
Analytical Chem. 56: 1752-1753, 1984.
Potter,
P.E., Hadjiconstantinou, M., Meek, J.L., and Neff, N.H.: Measurement of
Acetylcholine turnover rate in brain: an adjunct to a simple HPLC method for
choline and acetylcholine. J.
Neurochem. 43: 288-290, 1984.
Giorgi,
O., and Meek, J.L.: GABA turnover in rat striatum: Effects of glutamate and
kainic acid. J. Neurochem. 42,: 215-220, 1983.
Potter,
P.E., Meek, J.L., and Neff, N.H.: Acetylcholine and choline in neuronal tissue
measured by HPLC with electrochemical detection. J. Neurochem. 41:
188-194, 1983.
Meek,
J.L., Iadarola, M.J. and Giorgi, O.: Cholecystokinin turnover in brain. Brain
Res. 276: 375-378, 1983.
Meek,
J.L.: Derivatizing reagents for HPLC detection of peptides at the picomole level.
J. Chromatogr. 266: 401-408, 1983.
Korpi,
E.R., Phelps, B.H., Granger, H., Chang, W., Linnoila, M., Meek, J.L., and
Wyatt, R.J.: Simultaneous determination of haloperidol and its reduced
metabolite in serum and plasma by Isocratic Liquid chromatography with
electrochemical detection. Clin. Chem. 29: 624-628, 1983.
Meek,
J.L.: Neurochemical applications of
HPLC. In Hanin, I. (ed.) Dynamics of Neurotransmitter Function. New York, Raven
Press, 363-367, 1984.
Guidotti,
A., Konkel, D.R., Ebstein, B., Corda, M.C., Wise, B.C., Krutzch, H., Meek, J.L.
and Costa, E.: Isolation, characterization and purification to homogeneity of
GABA-modulin from rat brain. Proc. Nati. Acad. Sci. USA 79: 6084-6088,
1982.
Forchetti,
C.M., Marco, E.J. and Meek, J.L.: Serotonin
and GABA turnover after injection into the median raphe of substance P and
D-Ala-Metenkephalin amide. J. Neurochem. 38: 1336-1341, 1982.
Forchetti,
C.M. and Meek, J.L.: Neurotransmitter interactions in the median raphe nucleus.
In Usdin, E. (ed.): Structure and Function of Monoamine Enzymes. New York,
Raven Press, 1981, pp. 347-351.
Di
Lauro, A., Meek, J.L. and Costa, E.: Specific high affinity binding of 3H-aspartate
to rat brain membranes. J. Neurochem. 38: 1261-1267, 1982.
Meek,
J.L. and Rossetti, Z.L.: Factors affecting retention and resolution of peptides
in HPLC. J. Chromatogr. 211: 15-28, 1981.
Di
Lauro, A., Schmid, R.W. and Meek, J.L.: Is aspartic acid the neurotransmitter
of the perforant pathway? Brain Res. 207: 476-480, 1981.
Schmid,
R., Hong, J.S., Meek, J. and Costa, E.: The effect of kainic acid on the
hippocampal content of putative transmitter amine acids. Brain Res. 200:
355-362, 1980.
Forchetti,
C. M.,.and Meek, J. L.: Evidence for a tonic GABAergic control of serotonin
neurons in the median raphe nucleus. Brain Res. 206: 208-212, 1981.
Meek,
J.L.: Nomogram for reverse phase HPLC relating retention to mobile phase
composition. Anal. Chem. 52: 1370-1371, 1980.
Meek,
J.L. : Separation of neuropeptides by HPLC. Adv. Biochem. Psycopharmacol. 22:145-l5l,
1980.
Meek,
J.L.: Prediction of peptide retention times in high pressure liquid
chromatography on the basis of amino acid composition. Proc. Natl. Acad. Sci.
(USA) 77: 1632-1637, 1980.
Marco,
E.J., and Meek, J.L.: The effects of antidepressants on serotonin turnover in
discrete regions of rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology 706:
75-79,1979.
Meek,
J.L. and Bohan, T.P.: Use of high pressure liquid chromatography (HPLC) to
study enkephalins. Adv. Biochem. Psychopharmacol. 18: 141-147, 1979.
Bohan,
T.P., and Meek, J.L.: Met Enkephalin: Rapid separation from brain extracts
using high pressure liquid chromatography, and quantitation by bioassay.
Neurochem. Res. 3: 367-372, 1978.
Meek,
J.L.: Studies of Serotonin neurotoxins in discrete brain nuclei. Annals N.Y.
Acad. Sci. 305: 190-197, 1978.
Meek,
J.L., and Neckers, L.M.: Studies of serotonin turnover in discrete nuclei using
HPLC. In: Structure and Function of monoamine enzymes, Eds. E. Usdin, Weiner
and M. Youdin, Marcel Dekker, 1977.
Meek,
J. L., Yang, H.-Y. T. and Costa, E.: Enkephalin catabolism in vitro and in
vivo. Neuropharmacology, 16:151-154, 1977.
Neckers,
L. M. and Meek, J. L.: Measurement of 5HT turnover in discrete nuclei of rat
brain. Life Sci. 19: 1579-1584, 1976.
Meek,
J. L., Bertilsson, L., Cheney, D. L., Zsilla, G. and Costa, E.: Aging induced
changes in acetylcholine and serotonin content of discrete brain nuclei. J.
Gerontol., 32:129-131, 1977.
Neckers,
L. M., Biggio, G., Moja, E. and Meek, J. L.: Modulation of brain tryptophan
hydroxylase activity by brain tryptophan content. J. Pharmacol. exp. Therap., 201:110-116,
1977.
Meek,
J.L., and Lofstrandh, S., Tryptophan
hydroxylase: comparison of activity in
vivo and in vitro. Eur. J. Pharmacol., 37:
377-380, 1976.
Meek,
J.L., Applications of inexpensive
equipment for high pressure liquid chromatography to assays for taurine, GABA
and 5-hydroxytryptophan. Anal. Chem. 48: 375-379, 1976.
Neckers,
L. M., Bertilsson, L., Koslow, S., and Meek, J.L., Reduction of tryptophan
hydroxylase concentration in certain rat brain nuclei after
p-chloroamphetamine. 196:
333-338, 1976.
Meek,
J.L. and Bertilsson, L. Comparison of
the effects of lesions in the "B9" cell body group and
p-chloroamphetamine on tryptophan hydroxylase activity and
5-hydroxytryptamine. Brain Research, 100:
140-144, 1976.
Meek,
J.L., and Neckers, L.: Measurement of
tryptophan hydroxylase in single brain nuclei by high pressure liquid
chromatography. Brain Research, 91:
336-340,1975.
Foldes,
A., and Meek, J.L.: Occurrence and
Localization of brain phenolsulfotransferase.
J. Neurochem., 23: 303-307, 1974.
Costa, E., and Meek, J.L.: Regulation of biosynthesis of catecholamines and serotonin in the CNS. Ann. Rev. Pharmacol. 14: 491-511, 1974.
Anden,
N.E., Corrodi, H., Fuxe, K., and Meek,
J.L.: Hallucinogenic
phenylethylamines: interactions with
serotonin turnover and receptors. Eur.
J. Pharmacol. 20:176-184, 1974.
Meek,
J.L., and Foldes, A.: Sulfate
conjugates in the brain in: E. Usdin
and S. Snyder (Eds).: Frontiers in
Catecholamine Research London, Pergamon Press, pp. 167-171, 1973.
Foldes,
A., and Meek, J. L.: Rat brain phenolsulfotransferase -partial purification and
some properties. Biochimica Biophysica Acta 327:365-373, 1973.
Meek,
J. L. and Neff, N. H.: Is cerebrospinal fluid the major avenue for the removal
of 5-hydroxyindoleacetic acid from the brain? Neuropharmacol. 12:
497-499, 1973.
Meek,
J. L. and Neff, N. H.: The rate of formation of
3-methoxy-4-hydroxyphenylethyleneglycol sulfate in brain as an estimate of the
rate of formation of norepinephrine. J. Pharmacol. exp. Ther. 184:
570-575, 1973.
Costa,
E., Daly, J., LeFevre, H., Meek, J., Revuelta, A., Spano, F., and Strada, S.:
Serotonin and catecholamine concentrations in brain of rats injected
intracerebrally with 5,6-dihydroxytryptamine. Brain Research 44:
304-308, 1972.
Goridis,
C.J., Meek, J. L. and Neff, N. H.:
Monoamine oxidase activity of rat spinal cord after transection. Life Sciences 11:
861-866, 1972.
Meek,
J. L. and Neff, N. H.: Fluorimetric estimation of 3-methoxy
4-hydroxyphenylglycol sulfate in brain. Brit. J. Pharmacol. 45: 435-441,
1972.
Meek,
J. L. and Neff, N. H.: Acidic and neutral metabolites of norepinephrine: Their
metabolism and transport from brain. J. Pharmacol. exp. Ther. 181:457-462,
1972.
Meek,
J. L. and Neff, N. H.: Tryptophan 5-hydroxylase: approximation of half-life and
rate of axonal transport. J. Neurochem. 19: 1519-1525, 1972.
Meek,
J. L. and Fuxe, K.: Serotonin accumulation after monoamine oxidase inhibition.
Biochem. Pharmacol. 20: 693-706, 1971.
Meek,
J. L., Fuxe, K. and Carlsson, A.: Blockade of p-chloromethamphetamine induced
5-hydroxytryptamine depletion by chlorimipramine, chlorpheniramine, and
meperidine. Biochem. Pharmacol. 20: 707-709, 1970.
Meek,
J. L., Krall, A. R. and Lipton, M. A.: Psychotropic drugs and the metabolism of
intracerebrally injected tryptamine,
5–hydroxytryptamine and norepinephrine. J. Neurochem. 17:
1627-1634, 1970.
Prange,
A. J., Meek, J. L. and Lipton, M. A.: Catecholamines: diminished rate of
synthesis in rat brain and heart after thyroxine pretreatment. Life Sci. 9:
Part 1, 901-907, 1970.
Meek,
J. L. and Werdinius, B.: 5-Hydroxytryptamine turnover decreased by the
antidepressant drug chlorimipramine. J. Pharm. Pharmacol. 22: 142-143,
1970.
Meek,
J. L., Andén, N.E. and Fuxe, K.: Effects of antidepressant drugs of the
imipramine type on CNS 5-HT neurotransmission. Eur. J. Pharmacol. 9:
325-332, 1970.
Majchrowicz,
E., Lipton, M. A., Meek, J. L. and Hall, G.: Effects of chronic ethanol
consumption on the clearance of acutely administered ethanol and acetaldehyde
from blood in rats. Quart. J. Stud. Alcohol 29: 553-557, 1968.
Meek,
J. L., Majchrowicz, E. and Lipton, M. A.: Rates of C1402
production from labeled ethanol, acetate and glucose in alcohol drinking and
nondrinking rats. Proc. Soc. Exp. Biol. Med. 126: 379-383, 1967.